https://ogma.newcastle.edu.au/vital/access/ /manager/Index ${session.getAttribute("locale")} 5 Cross-protection and cross-feeding between Klebsiella pneumoniae and Acinetobacter baumannii promotes their co-existence https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:51223 Wed 28 Feb 2024 15:37:01 AEDT ]]> Robenidine analogues as gram-positive antibacterial agents https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:30033 1 (2,2′-bis[(4-chlorophenyl)methylene]carbonimidic dihydrazide), was active against MRSA and VRE with MIC’s of 8.1 and 4.7 μM, respectively. SAR revealed tolerance for 4-Cl isosteres with 4-F (8), 3-F (9), 3-CH₃ (22), and 4-C(CH₃)₃ (27) (23.7–71 μM) and with 3-Cl (3), 4-CH₃ (21), and 4-CH(CH₃)₂ (26) (8.1–13.0 μM). Imine carbon alkylation identified a methyl/ethyl binding pocket that also accommodated a CH₂OH moiety (75; 2,2′-bis[1-(4-chlorophenyl)-2-hydroxyethylidene]carbonimidic dihydrazide). Analogues 1, 27 (2,2′-bis{[4-(1,1-dimethylethyl)phenyl]methylene}carbonimidic dihydrazide), and 69 (2,2′-bis[1-(4-chlorophenyl)ethylidene]carbonimidic dihydrazide hydrochloride) were active against 24 clinical MRSA and MSSA isolates. No dose-limiting cytotoxicity at ≥2× MIC or hemolysis at ≥8× MIC was observed. Polymyxin B addition engendered Escherichia coli and Pseudomonas aeruginosa Gram-negative activity MIC’s of 4.2–21.6 μM. 1 and 75 displayed excellent microsomal stability, intrinsic clearance, and hepatic extraction ratios with T1/2 > 247 min, CLint < 7 μL/min/mg protein, and EH < 0.22 in both human and mouse liposomes for 1 and in human liposomes for 75.]]> Wed 02 Mar 2022 14:27:39 AEDT ]]> Antigiardial Activity of Novel Guanidine Compounds https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:50596 Tue 08 Aug 2023 11:56:57 AEST ]]> The influence of early-life microbial exposures on long-term respiratory health https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:53400 Thu 23 Nov 2023 13:43:38 AEDT ]]> A synbiotic mixture of selected oligosaccharides and bifidobacteria assists murine gut microbiota restoration following antibiotic challenge https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:53650 Thu 14 Dec 2023 12:49:00 AEDT ]]> Niche specialization and spread of Staphylococcus capitis involved in neonatal sepsis https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:44871 Mon 24 Oct 2022 11:16:35 AEDT ]]> Focus on early-career GPs: qualitative evaluation of a multi-faceted educational intervention to improve antibiotic prescribing https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:46567 Fri 25 Nov 2022 11:40:21 AEDT ]]> Temporal patterns of antibiotic prescribing for sore throat, otitis media, and sinusitis: a longitudinal study of general practitioner registrars https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:53147 Fri 17 Nov 2023 11:28:55 AEDT ]]>